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GP Oxy

General information:

Manufacturer: Geneza Pharmaceuticals
Substance: Oxymetholone
Pack: 50 tabs (50 mg/tab)

GP Oxy Review

GP Oxy was initially developed as a compound to help people with anemia, and has since been used very successfully to aid people who are suffering from many other diseases where weight loss is a concern. Thus, it is clearly an effective agent for promoting weight gain, increasing appetite, gaining strength, and increasing Red Blood Cell count. And, as with most Anabolic/Androgenic Steroids (AAS), it has it´s downsides as well. At our steroids pharmacy one may find GP Oxy online with its active substance Oxymetholone from Geneza Pharmaceuticals without prescription in packs of 50 tabs.

GP Oxy Effects

In order to gain a complete understanding of the GP Oxy (Anadrol) effects on body, it is necessary to take a look at its advantages contrasted with its disadvantages. Oxymetholone is a DHT-derived compound, and is 17-Alpha-Alkylated steroid, meaning that it has been altered at the 17th carbon position to survive oral ingestion. Most oral steroids are 17aa, and this helps them make it through your liver in a useful form.

GP Oxy Side Effects

GP Oxy will inhibit your body´s natural production of hormones (testosterone, etc& ), will negatively affect your blood lipid profile, can cause water retention, is notorious for causing headaches, and is also highly liver toxic (in fact, it has the worst reputation for hepatoxicity out of all steroids). Paradoxically, although one the benefits touted by it´s original manufacturer is that it can be used to stimulate weight gain through increasing appetite, taking too much may actually inhibit your appetite!

This 17aa alteration, which makes it possible for GP Oxy to survive its first pass through the liver, also makes it very taxing on your liver. The fact that GP Oxy causes some side effects has really never been in debate.

The gains from GP Oxy are quite dramatic for the first 3 weeks, and then quickly level off. Unfortunately, the side effects experienced from GP Oxy (which includes sometime a headache, bloating, elevated blood pressure, and a general "unwell" feeling) remain for the entire duration of use, as usual, side effects for this drug are pretty much half legend and half truth.

Since GP Oxy is derived from DHT, it can´t actually convert to estrogen (via the aromatase enzyme), and it´s not a progestin or a compound with progestenic activity so the estrogenic side effects produced by it are of a very mysterious nature. It has been speculated that perhaps it can stimulate the estrogen receptor without actually being converted to estrogen. However, things really get strange, when Oxymetholone has been used in studies to alter the female reproductive/menstrual cycle; in those cases, it has lowered plasma progesterone levels!

One would expect that an AI (aromatase inhibitor) wouldn´t be of much use with this drug, but many have found that Letrozole (which has, in some cases been shown to reduce estrogen in the body to an undetectable amount) can greatly reduce or even eliminate many of the more noticeable side effects of GP Oxy, such as the bloating.

As it can be concluded, the sides from this drug are certainly no joke, but are easily preventable, and controllable. One study even showed very few sides for subjects using up to 100mgs of Oxymetholone. Clearly, GP Oxy´s hepatoxicity has been a bit exaggerated, in some circles.

GP Oxy Usage

GP Oxy should be used in a cycle including injectable steroids, but not other 17aa compounds. Thus any 6-week-run of this compound begin at the start of a cycle, as a form of "jumpstart" towards seeing gains quickly. The quick gains that will occur from GP Oxy are also just as quick to disappear upon cessation of use, unless the bodybuilders is simply using it as a kickstarter, while waiting for his other compounds to kick-in.

I´ll go out on a limb here and say that utilizing Anadrol as a "Jumpstart" is the most popular use of this drug for athletes and bodybuilders today. I´ll also say that this drug is immensely popular with strength athletes who don´t have to worry about weight classes (Field athletes and strongmen), and with powerlifters in the heavier weight brackets. It´s also important to note that in one study by Schroder et. Al (2) anadrol showed that it has the ability to lower serum SHBG (Sex Hormone Binding Globulin& which binds to your free test and makes it no longer useful for anabolism, among other things) concentrations by 54.9 ± 25.8 and 45 ± 16.2 nmol/l in the 50- and 100-mg treatment groups. This means there will be more free test circulating around your body when you take this drug& clearly, this would produce some synergy when stacked with other steroids. Given the large amounts of weight and strength which can be gained in a relatively short time span on this drug, I´m sure this comes as no surprise to many.

Another important and often understated characteristic of this compound is that Oxymetholone doesn´t bind well to the androgen receptor (Relative Binding Affinity = too low to be determined) (3) which is the lowest I´ve ever read about. Basically, what this tells me is that there are a lot of non-receptor mediated effects from this steroid, making it a very potent addition to ANY BULKING stack, because it won´t be competing for the receptor sites with the other steroids you´re using. It´s also, as you may have guessed a very poor choice for a cutting stack.

GP Oxy Cycles

What is an Anadrol Cycle? How much should you use? Well, this is actually one of the most interesting facts about Anadrol. You see, most steroids produce what we call a "dose respondent curve" which is a fancy way of saying "the more you use, the more you gain."

Anadrol is one of the few steroids where the dose respondent curve flattens out very quickly. When you take 50mgs of Anadrol, you´ll make some very good gains. When you take 100mgs of Anadrol, you´ll make even more gains. However, it has been found that 100mgs/day is as effective for weight gain as 150mgs/day but produces less side effects and was less toxic (4). I feel that the jump from 50mgs to 100mgs constitutes an acceptable rise in benefit vs. cost, but this is not the case as dosages get over 100mgs. Now, lets see how 50mgs and 100mgs of Oxymetholone actually effect strength, when compared with each other:

Relative (%) changes in strength are shown for the groups receiving placebo (filled bars), 50 mg/day oxymetholone (open bars), and 100 mg/day oxymetholone (gray bars). Nos. above bars represent relative change (%) from baseline to week 12 for the 1-repetition maximum tests of strength. Error bars represent ± 1 SE from the mean. * Significant difference from placebo, P < 0.05; significant difference from placebo by Wilcoxon test, P < 0.02. See text for additional statistical analyses.

As you can see, in this study, doubling the dose of Anadrol nearly doubled the strength gains of the test subjects. Now, when we look at changes in body composition from Oxymetholone (chart below) we can see that although the guys taking the 100mgs (vs. the 50mgs group) had more fat lost and more Lean Body Mass gained, it wasn´t as dramatic as the differences in strength gains between the two groups:

Changes in body composition are shown for the groups receiving placebo (filled bars), 50 mg of oxymetholone per day (open bars), and 100 mg per day (gray bars). Numbers above the bars represent the mean absolute changes and the error bars are ± 1 SE. For total lean body mass (LBM) and total fat, differences among the 3 groups were significant (P < 0.0001, one-way ANOVA). * Significant differences from placebo, P 0.001.

Although I am usually not inclined to posit speculations on why a particular drug does or doesn´t do something, in this case I will. I´m guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body´s natural hormonal system, on par with most other oral steroids, but not as bad as most injectables, and it´s certainly not as harsh on your lipid profile as many anabolics are

Anadrol Body Building

(As an interesting side note, some of the medical literature on this compound suggests a dose of 1-5mgs per kg of bodyweight. I´ll pause a second here for you to figure out how absurdly high of a dose that would translate to for the average bodybuilder!

GP Oxy Profile

[17 beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one]
Active substance: (Oxymetholone)
Molecular Weight: 332.482
Molecular Formula: C 21 H 32 O 3
Melting Point: 178-180C
Manufacturer: Geneza Pharmaceuticals
Release Date: 1960
Effective Dose: 100mgs (optimal)
Active Life: <16hours
Detection Time: up to 8 weeks
Androgenic: Anabolic Ratio: 45:320